![]() “The level of dystrophin expression achieved with FORCE™ after a single dose in the mdx mouse model is substantial and the protein is widely expressed, with at least 80% dystrophin-positive fibers in both skeletal and cardiac muscle. “We are excited about the data from these latest studies in an established DMD in vivo model as well as in non-human primates as we prepare to advance our program into the clinic,” said Oxana Beskrovnaya, Ph.D., Dyne’s chief scientific officer. (Nasdaq: DYN), a muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases, announced new data being presented today during the 2021 Muscle Study Group Annual Scientific Meeting for its Duchenne muscular dystrophy (DMD) program that demonstrate robust and durable exon skipping and dystrophin expression in both cardiac and skeletal muscles in in vivo models. 01, 2021 (GLOBE NEWSWIRE) - Dyne Therapeutics, Inc. DYNE-251 in DMD and DYNE-101 in DM1, Co-Lead Programs Advancing to the Clinic and Focus of R&D Day on October 13. DYNE-251 Achieves Exon 51 Skipping of 52% in the Diaphragm and 43% in the Heart in Non-Human Primates and is Well Tolerated in GLP Toxicology Study. Dystrophin Restoration of 90% of Wild-Type Levels Observed in the Diaphragm and 78% in the Heart with ~80% Dystrophin-Positive Fibers After a Single Dose in mdx Mouse Model.
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